Which of the following correctly describes the mechanism of action of fibric acid derivatives?

Agonize peroxisome proliferator-activated receptor alpha (PPARa)

(B) is the correct answer here. Fibric acid derivatives are agonists of PPARa. The following will explain what that means. PPARa is a transcription factor that will transmit signals to genes. The receptor is expressed in the liver, kidney, heart, and muscle. Stimulation of the receptor leads to increased expression of lipoprotein lipase on cell membranes. Recall that this is to break down triglycerides contained in VLDL and chylomicrons into FFAs. As a result, there will be a decrease in triglycerides. Actually, more ApoE, which helps bind to the LDL receptor, will be able to help remove VLDL from the bloodstream to also reduce triglycerides. ApoCIII is another apoprotein that would normally inhibit lipoprotein lipase and is such decreased in expression. ApoA-I and ApoA-II are activated, which are responsible to help HDL carry cholesterol. (A) is the mechanism of action for niacin. (C) is the mechanism of action for statins. (D) is the mechanism of action for ezetimbe.