What is the most likely diagnosis?

A 30-year-old man has experienced pain in the area of the left knee for more than 1 month. On physical examination, there is tenderness to palpation of the distal left thigh and knee. The area is firm, but there is no erythema or warmth. A radiograph of the left leg shows a 7-cm mass in the distal femoral epiphyseal area, with a “soap bubble” appearance. Microscopic examination of a biopsy specimen of the lesion shows multinucleated cells in a stroma predominantly composed of spindle-shaped mononuclear cells.
1. Ewing sarcoma
2. Osteoblastoma
3. Enchondroma
4. Osteitis fibrosa cystica
5. Giant-cell tumor

Asked by Lola, Last updated: Apr 27, 2024

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1 Answer

John Smith

Answered Sep 09, 2016

Giant-cell tumor-(e) most cases of giant-cell tumor arise in the epiphyses of long bones of individuals 20 to 40 years old; there is aslight female predominance. the tumors may recur after curettage. although most are histologically and biologicallybenign, in rare cases, a sarcoma can arise in a giant-cell tumor of bone. ewing sarcoma is seen in the diaphyseal regionand usually manifests within the first 2 decades of life. an osteoblastoma usually involves the spine. enchondromas aremost often peripheral skeletal lesions involving the metaphyseal region of small tubular bones of the hands and feet.osteitis fibrosa cystica is a complication of hyperparathyroidism.bp7 769bp8 817pbd7 1302pbd8 1233