Causes cellular ph to raise, becoming more basic-hypoxia deprives the cell of oxygen and interrupts oxidative metabolism and the generation of atp. Can include ischemia; ischemia is characterized by impaired oxygen delivery and impaired removal of metabolic end-products.
In contrast to pure hypoxia, which affects the ocygen content of the blood and affects all of the cells in the body, ischemia commonly affects blood flow through small numbers of blood vessels and produces local tissue injury. Hypoxia literally causes a power failure in the cell, with widespread effects on the cells funtional and strucutral components. As oxygen tension in the cell falls, oxidative metabolism ceases, and the cell reverts to anaerobic metabolism, using its limited glycogen stores in an attempt to maintain vital cell functions. Cellular ph falls as lactic acid accumulates in the cell. The nuclear chromatin clumps.