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Which activity will be inhibited when the following patient is given appropriate pharmacotherapy?

Which activity will be inhibited when the following patient is given appropriate pharmacotherapy?

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A previously healthy 32-year-old man is brought to the emergency department because of a 1-day history of intermittent flashing spots and blurred vision, vomiting, confusion, and difficulty walking. He is a painter and says that yesterday he cleaned up a spilled bottle of paint thinner. Ophthalmologic examination shows dilated pupils with hyperemia of the optic disc and retinal edema. Physical examination shows tachypnea. Serum studies show an anion gap metabolic acidosis.

A. Alcohol dehydrogenase
B. Aldehyde dehydrogenase
C. Formaldehyde dehydrogenase
D. Lactate dehydrogenase
E. Pyruvate dehydrogenase

This question is part of NBME 13 section 1 (qst 1-50)
Asked by Wyatt Williams, Last updated: Sep 10, 2020

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6 Answers

marinasharif

marinasharif

marinasharif
Marinasharif

Answered May 11, 2017

FYI I put formaldehyde dehydrogenase and got it wrong. So the answer must be alcohol deH like @dochenaj said
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E. Barnes

E. Barnes

But Can you play this?

E. Barnes
E. Barnes, Professional Gamer, Professional Gamer, Washington

Answered Feb 26, 2019

The correct answer to this question is A. Alcohol dehydrogenase is a group of dehydrogenase enzymes, a class of zinc enzymes, that catalyze the oxidation of primary and secondary alcohols and facilitate the interconversion of alcohols and aldehydes with the reduction of hydride anion to NAD+ to NADH, the realease of a proton.

Alcohol dehydrogenase will be inhibited because it is the first step in the metabolism of both methanol and ethylene glycol. The patient has tachypea which is abnormally rapid breathing. The patient also has anion gap metabolic acidosis which is the result of type I diabetes, chronic alcoholism, or undernutrition.

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John Adney

John Adney

John Adney
John Adney

Answered Jun 16, 2017

I put A) Alcohol dehydrogenase and I got it right
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dochenaj

dochenaj

dochenaj
Dochenaj

Answered Mar 07, 2017

The most appropriate answer would be alcohol dehydrogenase considering it is the first step in the metabolism of both methanol and ethylene glycol.

While formaldehyde dehydrogenase is the second step only in the meta of methanol.
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amartyagain

amartyagain

amartyagain
Amartyagain

Answered Dec 02, 2016

Why not fomepizole(alcohol dehydrogenase inhibitor) which is the antidote of methanol poisoning.

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John Smith

John Smith

John Smith
John Smith

Answered Nov 07, 2016

Formaldehyde dehydrogenase
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