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Bleeding complications are frequently associated with fibrinolytic therapy. Which of the following statement(s) concerning complications of fibrinolytic therapy is/are true?



A. Careful monitoring of prothrombin time and aPTT time are necessary to avoid bleeding complications
B. A level of serum fibrinogen less than 100 mg/dl is associated with an increased risk of bleeding
C. Recent (less than 10 days) major surgery is a contraindication to systemic but not regional fibrinolytic therapy
D. A patient with a cerebrovascular event occurring less than two months ago can be treated with fibrinolytic therapy if head CT scan is normal

This question is part of basic surgery (100q).1

Asked by Samantha, Last updated: Sep 08, 2020

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1 Answer

John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

A level of serum fibrinogen less than 100 mg/dl is associated with an increased risk of bleeding-fibrinolytic therapy induces a hemostatic defect through a combination of factors. hypofibrinogenemia and fibrin degradation products inhibit fibrin polymerization and, in combination with a decrease in the clotting factors v and viii, prolong the ability of blood to clot. however, coagulation tests in general do not correlate well with bleeding complications. a level of fibrinogen less than 100 mg/dl is associated with an increased risk of bleeding. absolute contraindications to thrombolytic therapy include active internal bleeding, recent (less than 2 months) cerebral vascular accident, and documented left heart thrombosis. recent (less than 10 days) major surgery, obstetric delivery, organ biopsy, or major trauma is considered a major relative contraindication to either regional or systemic thrombolytic therapy.
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