None of the above-several important systemic factors or conditions influence wound healing. interestingly, there are no known systemic conditions that lead to enhanced or more rapid wound healing. overall nutrition as well as adequate vitamins play an important role in wound healing. vitamin a is involved in the stimulation of fibroplasia, collagen cross-linking, and epithelialization. although there is no conclusive evidence in humans, vitamin a may be useful clinically for steroid-dependent patients who have problematic wounds or who are undergoing extensive surgical procedures. vitamin c is a necessary cofactor in hydroxylization of lysine and proline in collagen synthesis and cross-linkage. the utility of vitamin c supplementation in patients who otherwise take in a normal diet has not been established. vitamin e is applied to wounds and incisions empirically by many patients. the evidence to support this practice is entirely anecdotal. in fact, large doses of vitamin e have been found to inhibit wound healing. zinc and copper are also important cofactors for many enzyme systems that are important to wound healing. deficiency states are seen with parenteral nutrition but are rare and readily recognized and treated with supplements. overall, vitamin and mineral deficiency states are extremely rare in the absence of parenteral nutrition or other extreme dietary restrictions. there is no evidence to support the concept that supranormal provision of these factors enhance wound healing in normal patients.