Which of the following drug was most likely given IV to this patient? - ProProfs Discuss
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Which of the following drug was most likely given IV to this patient?
A 32-year-old man suffering from a non-Hodgkin’s lymphoma presented with fever, a cough, increasing dyspnea and hemoptysis. The man was in the hospital for the second the cycle of chemotherapy. Chest radiograph disclosed diffuse alveolar infiltrates on the right lobe and multiple small cavitary lesions on the left lobe. A bronchoalveolar lavage revealed fungal forms typical of Aspergillus genus.



A. Flucytosine
B. Terbinafine
C. Griseofulvin
D. Amphotericin B
E. Nystatin

This question is part of block 15 pharm antifungal drugs

Asked by Jayden, Last updated: Sep 08, 2020

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1 Answer

John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

Amphotericin b-answer: d fungi of the genus aspergillus usually coexist with man in harmless symbiosis. in special circumstances, however, some species may play an opportunistic role in producing disease in humans. patients with chemotherapy-induced neutropenia or impaired immune responses by any cause are at high risk for invasive pulmonary aspergillosis, like in the present case. recent studies indicate that the isolation of aspergillus in bronchoalveolar lavage fluid correlates strongly with histologic evidence of parenchymal invasion. the disease is treated with amphotericin b, but most patient die within few weeks of the diagnosis. a) flucytosine is effective in vitro against aspergillus species, but is not used clinically alone and even the addition to amphotericin b does not seem to add significant benefit. b, c) these antifungal drugs are not effective against aspergillus species. e) nystatin is too toxic for parenteral administration and is only used topically.
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