Which of the following skin structure was most likely the site of action of the prescribed drug?
A 31-year-old man presented to his physician with an annular lesion with raised
borders in his left hand. Microscopic examination of skin scrapings revealed branching
hyphae. The diagnosis of tinea manus was made and the patient was prescribed an
appropriated oral treatment.
A. Stratum basale B. Stratum spinosum C. Stratum corneum D. Pigment layer E. Hair follicle F. Hair shaft
Stratum corneum-answer: ctinea manus is a cutaneous mycosis caused by dermatophytes that infect only the superficial,keratinized tissues. these fungi are probably restricted to the nonviable, keratinized tissues(stratum corneum, hairs, nails) because most are unable to grow at 37 c. dermatophytoses canbe treated locally with several antifungal drugs, but the drugs of choice for systemic treatmentare griseofulvin or terbinafine. these drugs have a good oral bioavailability and are depositedin newly formed keratinized tissues where they exert their antifungal action.a, b, d, e) (see explanation above)f) griseofulvin or terbinafine can be deposited in the hair shaft, where they can cure tineacapitis, but in the present case the fungus is in the skin stratum corneum, not in the hair.