Which of the following statements best explains the mechanism of antifungal action of
A. Inhibition of conversion of squalene to lanosterol B. Formation of artificial pores in the fungal membrane C. Inhibition of fungal mitosis D. Inhibition of squalene synthesis E. Inhibition of conversion of lanosterol to ergosterol
Inhibition of conversion of lanosterol to ergosterol-answer: eazoles inhibit cytochrome p450 enzymes. this inhibition impairs the activity of a p450-dependent lanosterol demethylase that converts lanosterol to ergosterol. the ultimate effect isan inhibition of ergosterol synthesis in fungal cells. the specificity of azole drugs results fromtheir greater affinity for fungal than for mammalian cytochrome p450 enzymes. imidazoles (i.eketoconazole) have a lesser degree of specificity than triazoles (i.e. fluconazole).a) this would be the mechanism of action of terbinafine.b) this would be the mechanism of action of amphotericin bc) this would be the mechanism of action of griseofulvin.d) no antifungal drug can inhibit the synthesis of squalene. in mammalian cells this synthesiscan be inhibited by hmg-coa reductase inhibitors through an inhibition of the synthesis ofmevalonate.