Which of the following statements best explains the mechanism of - ProProfs Discuss
Cancel
TopicsDown
Products Down
Follow Us:
FacebookTwitter
Advertisement

Which of the following statements best explains the mechanism of antifungal action of azoles?



A. Inhibition of conversion of squalene to lanosterol
B. Formation of artificial pores in the fungal membrane
C. Inhibition of fungal mitosis
D. Inhibition of squalene synthesis
E. Inhibition of conversion of lanosterol to ergosterol

This question is part of block 15 pharm antifungal drugs

Asked by Klayton, Last updated: Sep 08, 2020

+ Answer
Request
Question menu
Vote up Vote down

1 Answer

John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

Inhibition of conversion of lanosterol to ergosterol-answer: eazoles inhibit cytochrome p450 enzymes. this inhibition impairs the activity of a p450-dependent lanosterol demethylase that converts lanosterol to ergosterol. the ultimate effect isan inhibition of ergosterol synthesis in fungal cells. the specificity of azole drugs results fromtheir greater affinity for fungal than for mammalian cytochrome p450 enzymes. imidazoles (i.eketoconazole) have a lesser degree of specificity than triazoles (i.e. fluconazole).a) this would be the mechanism of action of terbinafine.b) this would be the mechanism of action of amphotericin bc) this would be the mechanism of action of griseofulvin.d) no antifungal drug can inhibit the synthesis of squalene. in mammalian cells this synthesiscan be inhibited by hmg-coa reductase inhibitors through an inhibition of the synthesis ofmevalonate.
upvote downvote
Reply 

Advertisement
Advertisement
Search for Google images Google Image Icon
Select a recommended image
Upload from your computer Loader
Image Preview
Search for Google images Google Image Icon
Select a recommended image
Upload from your computer Loader
Image Preview
Search for Google images Google Image Icon
Select a recommended image
Upload from your computer Loader

Email Sent
We have sent an email to your address "" with instructions to reset your password.