Which of the following statements correctly pair the antifungal drugs with their likely mechanism of action?
A. Amphotericin B - inhibits thymidylate synthetase B. Griseofulvin - interferes with microtubule function C. Flucytosine - inhibits fungal mycolic acid synthesis D. Miconazole - inhibits DNA dependent RNA polymerase E. Nystatin - inhibits ergosterol synthesis F. Terbinafine - inhibits squalene epoxidase
Griseofulvin - interferes with microtubule function-2. terbinafine - inhibits squalene epoxidase-answer: bf
griseofulvin is effective only against dermatophytes which take up the drug via an active
transport system. its exact mechanism of action is still unclear but the drug appears to
disrupt the mitotic spindle trough interaction with microtubules.
terbinafine (also effective mainly against dermatophytes) blocks the conversion of squalene to
lanosterol by inhibiting the fungal enzyme squalene epoxidase
a) inhibition of thymidylate synthetase would be the mechanism of action of flucytosine.
c) inhibition of mycolic acid synthesis would be the mechanism of action of isoniazid.
d) inhibition of dna dependent rna polymerase would be the mechanism of action of rifampin
e) inhibition of ergosterol synthesis would be the mechanism of action of azoles.