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A child with sickle cell anemia is seen in a hematology clinic. Her mother states that she has been feeling very tired lately, and may have "come down with a virus." On physical examination, the girl is very pale, and a complete blood count shows severe anemia. A bone marrow aspirate contains no erythroid precursor cells. The girl was probably infected with which of the following viruses?



A. Coxsackie virus
B. Echovirus
C. Hepadnavirus
D. Herpes virus
E. Parvovirus

This question is part of usmle microbiology prt 2

Asked by Ewing, Last updated: Sep 14, 2020

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1 Answer

John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

Parvovirus-the correct answer is e. parvoviruses are small single-stranded dna viruses, of which only serotype b19 is pathogenic for humans. this virus causes three distinct syndromes: a childhood febrile rash known as erythema infectiosum (fifth disease); aplastic crisis in individuals with chronic hemolytic diseases (sickle cell anemia, thalassemia, etc); and congenital infections that can present as stillbirth, hydrops fetalis (analogous to severe rh incompatibility), or severe anemia. coxsackie viruses (choice a) usually cause cold-like illness, but can cause herpangina, myocarditis, and meningitis. echoviruses (choice b) can infect a variety of organ systems (gi, cns, eyes, heart, respiratory, skin), but are not a cause of aplastic crises. hepadnavirus (choice c) is the causative agent of hepatitis b. herpes viruses (choice d) cause a variety of acute to chronic infections including herpes simplex types i and ii, chicken pox, chronic herpes zoster, cmv infection, and epstein barr virus infections.
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