Which of the following is the main advantage of this drug over the - ProProfs Discuss
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Which of the following is the main advantage of this drug over the standard unfractionated heparin?
A 67-year-old woman was admitted to the hospital because of a progressive swelling and soreness of the left calf. After physical examination and lab exams, a diagnosis of deep venous thrombosis was made and a treatment with enoxaparin was started.



A. Complete absence of bleeding complications
B. Good oral bioavailability
C. Lower incidence of drug-induced thrombocytopenia
D. Pronounced antiplatelet activity
E. Inhibitions of a larger number of coagulation factors

This question is part of block 10 pharm anticoagulation drugs

Asked by Erin, Last updated: Sep 08, 2020

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1 Answer

John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

Lower incidence of drug-induced thrombocytopenia -learning objective: describe the main advantages of lmwhs over standard heparin. answer: c hmwh causes transient thrombocytopenia in up to 15% of patients and severe thrombocytopenia (which is antibody-mediated) in up to 5% of patients. lmwhs-induced thrombocytopenia is < 1%. a) lmwhs cause a lower incidence of bleeding complications, which could be related to the fact that these agents preferentially inhibit factor xa more potently than they inhibit thrombin (thrombin inhibition requires a larger heparin molecule). nevertheless bleeding complications do occur even with lmwh. b) the oral bioavailability of both hmw and lmw heparins is zero. d, e) lmwhs do not have antiplatelet activity and they actually inhibit less coagulation factors than standard heparin.
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