Which one of the following drugs was most likely administered in the given-below case?
A 42-year-old woman presented to her ophthalmologist because of loss of central vision and pain on movement of her left eye. She reported that in the past she had had recurrent episodes of weakness and abnormal sensations in her ARMS and legs. The patient was referred to the neurologic clinic where labs exams and brain MRI confirmed the diagnosis of multiple sclerosis. The patient was prescribed a supportive therapy which included a recombinant cytokine endowed with immunostimulant properties.
A. Trastuzumab B. Infliximab C. Interferon beta-1b D. Prednisone E. Tacrolimus
Interferon beta-1b-answer: c( dipiro, pp 1023, lane pp 1476)interferon beta-1b is a cytokine produced by various cells including fibroblasts and macrophages. likeother interferons it has antiviral, immunomodulating and antiproliferative activities. interferon beta-1bwas the first agent shown to have an effect on the course of multiple sclerosis. the exact mechanism ofits action is still unknown but it is likely related to its immunomodulating properties, including the downregulation of the expression of class ii major histocompatibility complex and of interferon gamma. it isthought that interferon gamma is a major factor responsible for triggering the autoimmune reactionleading to multiple sclerosis. it stimulates cytotoxic t cells and induces macrophages to produceproteinases that degrade the myelin sheath around the spinal cord.a, b, d, e) these drugs are not recombinant cytokines.