A 47-year-old woman recently diagnosed with spasmodic torticollis received multiple
injections of a drug into the dystonic muscles of the neck. The therapy improved the
position of the head and reduced painful muscle spasms for 3 months after the
injections. Which of the following drugs was most likely administered?
A. Succinylcholine B. Botulin toxin C. Mivacurium D. Tubocurarine E. Dantrolene
Botulin toxin-learning objective: describe the therapeutic uses of botulin toxin.answer: bspasmodic torticollis is an involuntary tonic contraction of the neck muscles causing painfulspasm and abnormal head position. in severe cases the selective denervation of the neckmuscle is the most successful surgical approach but injection of botulin toxin into the dystonicmuscles of the neck can reduce the symptoms for 1 to 3 months in about 70% of patients .botulin toxin inhibits acetylcholine release from cholinergic terminals, so weakening skeletalmuscle contractions.a, b, c) neuromuscular blocking drugs are of no value in this disease mainly because of theirshort duration of action.e) spasmolytic drugs (dantrolene, benzodiazepines, tizanidine, etc.) are sometimes used butthey decrease spasms in only about 25% of cases.