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A 49-year-old man diagnosed with inguinal hernia was prepared for surgery. Shortly after the initiation of general anesthesia with halothane and succinylcholine the patient developed muscle rigidity, tachycardia, labile blood pressure, profuse diaphoresis and high fever. The anesthesia was discontinued at once and a drug was administered by rapid IV push. Which of the following was most likely the mechanism of action of the administered drug?



A. Activation of GABA B receptors in the spinal cord
B. Blockade of excitatory neurotransmitter release in the brain
C. Blockade of CA++ channels in skeletal muscle membrane
D. Blockade of CA++ channels in sarcoplasmic reticulum
E. Increased K+ conductance in skeletal muscle membrane
Asked by Millie, Last updated: Sep 08, 2020

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1 Answer

John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

Blockade of ca++ channels in sarcoplasmic reticulum-learning objective: explain the mechanism of action of dantroleneanswer: dthe clinical picture of the patient suggest the diagnosis of malignant hyperthermia, a rare butpotentially life-threatening disorder that can be triggered by a variety of stimuli, including theadministration of certain anesthetics and neuromuscular blocking agents. the disorder isrelated to an hereditary impairment in the ability of sarcoplasmic reticulum to sequester calciumand therefore a prolonged release of calcium occurs after the triggering event. this causesmassive muscle contraction, hyperthermia and lactic acidosis. dantrolene is a drug of choice inthis disorder because it blocks ca++ channels in sarcoplasmic reticulum of skeletal muscle.cardiac and smooth muscle are minimally affected by dantrolene since they have a differenttype of ca++ channel in their sarcoplasmic reticulum.a, b, c, e) (see explanation above)
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