What is the importance of citrate in fatty acid metabolism? - ProProfs Discuss
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What is the importance of citrate in fatty acid metabolism?

Asked by Steward Athinao, Last updated: Jul 09, 2021

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3 Answers

Karthikeyan Pethusamy

Karthikeyan Pethusamy

Author of "Passing MBBS series - Biochemistry for undergraduates"

Karthikeyan Pethusamy
Karthikeyan Pethusamy, Research Associate, AIIMS, Delhi, MBBS MD DNB, Delhi

Answered Sep 08, 2019

Citrate helps in the polymerization of acetyl-CoA carboxylase.

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Sapen Ere

Sapen Ere

Sapen Ere
Sapen Ere

Answered Sep 05, 2019

Activation of fatty acid synthase

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John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

Activation of acetyl-coa carboxylase-fa synthesis and b-oxidation must not occur at the same time (futile cycle) compartmentalization: fa synthesis in cytosol, breakdown in mitocondria malonyl-coa (substrate for fa synthesis) shuts down carnitine shuttle (rate-limiting step of fa breakdown) fa synthesis regulated at acetyl-coa carboxylase: citrate signals good nutrition: allosteric insulin=dephosphorylation=activation glucagon + adrenalin=inc camp =phosphorylation=inactivation gene expression: insulin, glucagon# ( slide 57 f.a metab-bux)
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