Substantia nigra-the substantia nigra contains a large population of melanin-containing cells, is located in the midbrain just internal to the crus cerebri, and the loss of these cells gives rise to the motor deficits characteristic of parkinson disease. the neurotransmitter associated with these cells is dopamine. the reticular formation is in the core of the brainstem and the pontinenuclei are in the basilar pons; neither of these contains cells with melanin. the red nucleus is in the midbrain, but its red-dish tone is related to a rich vascular supply, not to cells containing a pigment.(p.133135)
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