What is the resting potential of large nerve fibers? - ProProfs Discuss
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What is the resting potential of large nerve fibers?

Asked by Jessica, Last updated: Jul 03, 2021

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John Smith

John Smith

John Smith
John Smith

Answered Sep 09, 2016

90 MV.

90 MV more negative inside fiber than in extracellular fluid - na+-k+ pump influences both ion concentrations & electropotential.

Leakage: channel protein exist in nerve membrane which k+ and na+ can leak, emphasis on k+ because 100 times more permeable to k+ - if k+ is the only ion to move through the membrane, the resting potential inside fiber would equal -94 mv (1:35 inner/outer ratio). Slight permeability of na+ through leak channels + nernst potential of +61 mv (10:1 inner/outer ratio), brings resting potential to -86 mv (ghk) - na+/k+ pump creates additional -4 mv, bringing resting potential to -90 mv.

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