Which neural cell bodies' absence causes the following condition?

A 6-year-old girl comes to her pediatrician with constipation, abdominal distention, and vomiting. After thorough examination, she is diagnosed as having Hirschsprung's disease (aganglionic megacolon), which is a congenital disease and leads to dilation of the colon.

Asked by Chachelly, Last updated: Apr 10, 2024

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1 Answer

John Smith

Answered Apr 21, 2017

Parasympathetic postganglionic neuron cell bodies

Aganglionic megacolon (Hirschsprungs disease) is caused by the absence of enteric ganglia (parasympathetic postganglionic neuron cell bodies) in the lower part of the colon, which leads to dilatation of the colon proximal to the inactive segment, resulting in an inability to evacuate the bowels. The other neuron cell bodies listed are not involved in this condition.