VDRL and RPR are tests used to confirm the diagnosis of syphilis, especially at the early stages. VDRL stands for Venereal Disease Research Laboratory, and RPR is the acronym for Rapid Plasma Reagin.
The advantage of VDRL over RPR is that Cerebrospinal Fluid (CSF) can be used as a specimen to carry out the test, but this is not the case for RPR. It is important to know that RPR is actually more advance for diagnosing syphilis, and it is faster and easier to perform.
This significant difference between both is that VDRL can be used to diagnose neurosyphilis. These tests can be used to monitor the course of syphilis before and after treatment.
CSF can be used as a specimen for VDRL. VDRL is an acronym for Venereal Disease Research Laboratory, and RPR is the acronym for Rapid Plasma Reagin. One major advantage that VDRL has over RPR is that VDRL can use Cerebrospinal Fluid (CSF) as a specimen for the test. This gives VDRL an edge over RPR when it comes to the use of CSF as a specimen. RPR is much advanced and developed than VDRL.
It is the most preferred test for syphilis because it can be easily done. For the VDRL test, the specimen most be heated before the test can be done, but this is not the case for RPR. RPR is more effective in detecting syphilis infection. RPR can also be done with the use of a microscope, as a result, is visible with the naked eye. The reverse is the case for VDRL.
One advantage of VDRL (Venereal Disease Research Laboratory) over RPR (Rapid Plasma Reagin) is that it can use CSF (or cerebrospinal fluid) as a testing agent. That said, the RPR test is actually the better version of the test. Neither are quite effective for detecting syphilis later on in the disease’s progression, but both are amazing for detecting it early.
VDRL actually requires that a specimen be heated before testing, but RPR doesn’t. In reality, RPR is simply a more advanced version of VDRL. Both of them can be used to detect syphilis early on if you suspect it, and both are the same procedure. That said, having to get a specific sample for an RPR specimen could make it more difficult for practitioners on a time crunch.