Which statement about phenytoin is accurate? - ProProfs Discuss
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Which statement about phenytoin is accurate?



A. Displaces sulfonamides from plasma proteins
B. Drug of choice in myoclonic seizures
C. Half-life is increased if used with phenobarbital
D. Isoniazid decreases steady-state blood levels of phenytoin
E. Toxic effects may occur with only small increments in dose

This question is part of Pharmacology Test 3
Asked by Rlg, Last updated: Oct 19, 2020

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2 Answers

John Adney

John Adney

John Adney
John Adney

Answered Jan 31, 2017

1displaces sulfinamides from plasma protein
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John Smith

John Smith

John Smith
John Smith

Answered Dec 23, 2016

Toxic effects may occur with only small increments in dose

Sulfonamides can displace phenytoin from its binding sites, increasing the plasma-free fraction of the drug. Induction of liver drug-metabolizing enzymes by phenobarbital results in a decreased half-life of phenytoin, and isoniazid increases plasma levels of phenytoin by inhibiting its metabolism. Because of the dose-dependent elimination kinetics of phenytoin, some toxicity may occur with only small increments in dose.
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