What is the difference between MiRNA and SiRNA? - ProProfs Discuss
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What is the difference between MiRNA and SiRNA?

Asked by B. Wright, Last updated: Sep 29, 2020

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3 Answers

Todd Gurley

Todd Gurley

Todd Gurley
Todd Gurley

Answered Sep 29, 2020

MiRNA and SiRNA are two types of RNA that are non-coding. They are related to the field of molecular biology. MiRNA is an abbreviation that stands for micro ribonucleic acid. It is a natural molecule and it includes one strand.

This strand includes 22 nucleotides and it is normally found in animal cells, also known as eukaryotes. SiRNA is also an abbreviation. It stands for small interfering ribonucleic acid. Compared to MiRNA, SiRNA is double-stranded.

SiRNA can be natural, but most times it will be synthetic. They also differ in how they bind to the genome. MiRNA can pair imperfectly, while SiRNA requires the pairing to be perfect.

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Anika Nicole

Anika Nicole

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Anika Nicole
Anika Nicole, Wordsmith, PG In Journalism, New York

Answered Sep 25, 2019

MiRNA and SiRNA are both discussed in molecular biology. MiRNA stands for micro ribonucleic acid while SiRNA stands for small interfering ribonucleic acid. MiRNA is a type of natural molecule that comes with a single strand. This comes with 22 nucleotides and the location of this is usually in eukaryotes, which means animal cells. SiRNA is different from MiRNA in some ways. For example, SiRNA is double−stranded.

MiRNA and SiRNA are both discussed in molecular biology. MiRNA stands for micro ribonucleic acid
There are also instances when the SiRNA is synthetic, although it can also be available naturally. The MiRNA is usually very useful for the genome but will bind to various parts of it imperfectly. The SiRNA will fit the parts that are needed perfectly.

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W. Kaye

W. Kaye

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W. Kaye
W. Kaye, Ex-Marine, Post Graduate, Chapel Hill

Answered Aug 22, 2019

Two types of non-coding RNA that are included in gene regulation are MiRNA and SiRNA. Both are short, duplex RNA molecule exerting gene silencing effects by targeting messenger RNA at the post-transcriptional level. miRNA is an RNA duplex, which consists of 18-25 nucleotides. siRNA is a 21-23 nucleotide long duplex molecule. miRNA is capable of targeting over 100 mRNA types at the same time. siRNA is capable of selecting only one mRNA type.

Two types of non-coding RNA that are included in gene regulation are MiRNA and SiRNA. Both are
miRNA is partially complementary to the mRNA and chiefly targets the untranslated regions of the miRNA. siRNA can target only one mRNA type. miRNA is found in animals and plants. siRNA is located in lower animals and plants, but not in mammals. Also, miRNA aids as a drug target, therapeutic agent, or diagnostic and biomarker tool. siRNA aids as a therapeutic agent.

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