Spanish didn’t try to establish trade relations with the American empires because that was not their goal. The goal of the Spanish was to colonize the Americas.
One of their goals of colonization had to do with gaining more land to control so they could compete with their rivals. Spain was competing with other European countries for power and control throughout the world.
They were also hoping to find resources most especially gold and silver that will boost their own economy and treasury. Another reason for colonization in the Americas was to spread their religion, Spanish were Catholic and they wanted to spread their work across the region.