What is the correct dosing for tPA (Alteplase) in acute ischemic stroke?

Infuse 0.9 mg/kg (max dose 90 mg) over 60 minutes
Administer 10% of the dose as a bolus over 1 minute

The dosing for Alteplase is 0.9 mg/kg (max dose 90 mg) over 60 minutes, with 10% of the dose given as a bolus over 1 minute. For a 100 kg patient, the dose would be 90 mg total, with 9 mg given as the bolus and 81 mg given over the rest of the hour. For a 70 kg patient, then dose would be 63 kg total, with 6.3 mg given as a bolus and 56.7 mg given over the rest of the hour.