Which of the following is true regarding ezetimibe?

It is synergistic with statins for LDL-lowering effects

(E) is the correct answer. All of the above are true regarding ezetimibe. The following will explain why that is the case. (A) is true, as mentioned before. The combination effect of these two drug classes will help decrease teh compensatory cholesterol synthesis by the liver due to the loss of cholesterol from ezetimibe. The synergistic effect grants about a 21% decrease in LDL. (B) is also true. Most drugs have some sort of GI adverse effect of nausea or vomiting. This is relatively uncommon, though. (C) is true because bile acid sequestrants can decrease the absorption of drugs due to its resins. That is indeed the case here. (D) is true. It seems that cyclosporine interacts with many drugs, and that is the case. That is the same thing here as concentrations of ezetimibe may increase in the presence of cyclosporine.