Salamanders can regrow new tissue to replace entire limbs and regenerate parts of their major organs, which is an ability that lies in the immune systems. The salamander reveals immune cells called macro phases which are part of the early stages of regenerating lost limbs. Salamanders and newts display the highest regenerative ability among tetrapods.
Lizards can also regrow lost limbs, as well as frogs. Lizards can lose their tails on purpose, and they can regrow them. When a leg or tail is amputated, the newt generates a cell mass called the blastema, and the new fully functional limb is regenerated.