Yes, the number and size of the holes on the ball in Pickleball will affect both its speed and behaviour. Pickleball may be played outdoors with a Dura ball.
This has 56 holes, but for indoor play the ball has much larger holes, so it does not travel as fast as a Dura ball. It also has only 42 holes. The changes in ball behaviour were made because breakages were occurring.
The original Dura ball had 56 holes but this was reduced to 40 to increase the speed and prevent breakage. An indoor ball has much larger holes and therefore does not travel as fast as a harder Dura outdoor ball